Donnell, 62, is believed to have dementia/Alzheimers. The Springfield Police Department said she is paranoid and often arms herself with blunt objects.
Donnell is 5 feet 11 inches tall, 180 pounds, with gray-blonde hair and blue eyes. She may be wearing dark slacks and a dark blue floral shirt with a gold pattern.
Her vehicle, a silver 2002 Honda Civic with the Missouri license plate FM1K0E, was last seen at her residence.
Anyone with any information about Donnell or her vehicle is encouraged to call 911 or the Springfield Police Department at 417-864-1786.
Police say Sylvia Donnell, 62, disappeared Sunday around 6 p.m. from her residence in the 800 block of South Missouri Ave. Police say she is safe.